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α-PVP, like other psychostimulants, can cause hyperstimulation, paranoia, and hallucinations. α-PVP has been reported to be the cause, or a significant contributory cause of death in suicides and overdoses caused by combinations of drugs. α-PVP has also been linked to at least one death where it was combined with pentedrone and causedheart failure

α-Pyrrolidinopentiophenone (also known as α-pyrrolidinovalerophenone, α-PVP, O-2387, β-keto-prolintane,Prolintanone, or Desmethyl Pyrovalerone) is a synthetic stimulant of the cathinone class developed in the 1960s that has been sold as a designer drug. Colloquially it is sometimes calledflakka or gravel. α-PVP is chemically related to pyrovalerone and is the ketone analog of prolintane.

Methaqualone, sold under the brand name Quaaludein the US and Mandrax in the UK and South Africa, is medication. It is a member of the e class.

The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s. In 1962, methaqualone was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a or the treatment

Etaqualone (Aolan, Athinazone, Ethinazone is a class and is an analogue of that was developed in the 1960s and marketed mainly in France and some other European countries. It has and properties resulting from its agonist activity at the β-subtype of the, and was used for the treatment of

Flunitrazepam, also known as Rohypnol among others,is an intermediate acting used in some countries to treat severe insomnia and in fever, early in anesthesia.Just as with other hypnotics, flunitrazepam should be strictly used only on a short-term basis or by those with chronic insomnia on an occasional basis. Flunitrazepam has been referred to as a even though its incidence is very rare in cases that have been reported.

Isopropylphenidate (also known as IPH and IPPD) is a based drug, closely related to but with the methyl replaced by an ester. It has similar effects to methylphenidate but with a longer duration of action, and was banned in the UK as a T from April 2015 following its unapproved sale as a It is illegal in Lithuania to use, buy, possess, transport, sell or import Isopropylphenidate

25I-NBOMe (2C-I-NBOMe, Cimbi-5, also shortened to “25I”, and colloquially referred to as “N-bomb” is a and derivative of the psychedelicIt was discovered in 2003 by chemist Ralf Heim at the who published his findings in his PhD dissertation. The compound was subsequently investigated by a team at led by

Nimetazepam (marketed under brand name Erimin and Lavol) is an intermediate-actingdrug which is a derivative. It was first synthesized by a team at Hoffmann-La Roche in 1962. It possesses andproperties. Nimetazepam is also an It is sold in 5 mg tablets known as Erimin and Lavol. It is generally prescribed for the short-term treatment of in patients who have difficulty falling asleep or maintaining sleep. The sole global manufacturer of Nimetazepam (Sumitomo Japan) has ceased manufacturingErimin since early November 2015. Patients being prescribed Erimin are being switched to other hypnotics, e.g. etc.

2C-B or 2,5-dimethoxy-4-bromo is a of the. It was first synthesized by in 1974. In Shulgin’s book , the dosage range is listed as 12–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is also referred to by a number of other names.The drug is usually taken orally, but can also be or vaporized.

6-MAPB (1-(benzofuran-6-yl)-N-methylpropan-2-amine) is a psychedelic and entactogenic drug which is structurally related to 6-APB and MDMA. It is not known

5-MAPB (1-(benzofuran-5-yl)-N-methylpropan-2-amine) is an similar to on its structure and effects.

Oxycodone has been in clinical use since 1916, and it is used for managing moderate to moderately severe acute or chronic It has been found to improve for those with many types of pain.[ Experts are divided regarding use for non cancer-related chronic pain, as most opioids have great potential for dependence and may also create

Diclazepam (Ro5-3448), also known as chlorodiazepam and 2′-chloro-diazepam, is a . It was first synthesized by and his team at Hoffman-La Roche in 1960.It is not currently approved for use as a medication, but rather sold as a Efficacy and safety have not been tested in humans.

Ergotamine is an and part of the family o; it is structurally and biochemically closely

related to It possesses structural similarity to several and has as a
It is used for treatment of acute attacks (sometimes in combination with Medicinal usage of ergot fungus began in the 16th century to induce yet dosage uncertainties discouraged the use. It has been used to prevent (bleeding after childbirth). It was first isolated from the ergot fungus and marketed as Gynergen in 1921

N-Ethylhexedrone (also known as α-ethylaminocaprophenone, N-ethylnorhexedrone, hexen andNEH) is of the classN-Ethylhexedrone was first mentioned in a series of patents by in the 1960s which lead to the development of the better known drug (MDPV). Since the mid-2010s, N-ethylhexedrone has been sold online

Fuambai Sia Ahmadu (born c. 1969 is a Sierra Leonean-American anthropologist. She has worked for and the British lin the Gambia.

Ahmadu obtained her PhD in social anthropology from the and undertook post-doctoral work at the Department of Comparative Human Development,

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Fentanyl provides some of the effects typical of other opioids through its agonism of the . Its strong potency in relation to that of morphine is largely due to its highper the Because of this, it can more easily penetrate the

BROMADOLINE is the same effect with u-47700

Alprazolam is mostly used to treat and due to The FDA label advises that the physician should periodically reassess the usefulness of the drug. Alprazolam may also be indicated for the treatment of generalized anxiety disorder, as well as for the treatment of anxiety conditions with co-morbid depression. Alprazolam is also often prescribed with instances co-morbid sleep deficits.

α-PVP, like other psychostimulants, can cause hyperstimulation, paranoia, and hallucinations. α-PVP has been reported to be the cause, or a significant contributory cause of death in suicides and overdoses caused by combinations of drugs. α-PVP has also been linked to at least one death where it was combined with and caused

Ethylone, also known as 3,4-methylenedioxy-N-ethylcathinone (MDEC, βk-MDEA), is classified as an , and of theIt is the of (“Eve”). Ethylone has only a short history of human use and is reported to be less potent than its relative In the United States, it began to be found in cathinone products

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MDMB-CHMICA (also incorrectly known as MMB-CHMINACA) is anbased that is a potent of the t and has been sold online While MDMB-CHMICA was initially sold under the name “MMB-CHMINACA”, the compound corresponding to this code name (i.e. the isopropyl instead of t-butyl analogue of has been identified on the designer drug market in 2015 as amb-chminaca

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5F-AB-PINACA is anthat is derived from a series of compounds originally developed by in 2009 as medication, and has been sold online

5F-AB-PINACA has been reported to be a potent of the andwith values of 0.48 nM and 2.6 nM respectively.Its metabolism has been described in literature.

U-50488 is a drug which acts as a highly selective , but without any effects. It has cand effects,and reverses the memory impairment produced by drugs. U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds

3-Methoxyeticyclidine (3-MeO-PCE) is that is qualitatively similar to PCE AND PCP and has been sold online as

4-Methoxyphencyclidine (methoxydine, 4-MeO-PCP) is a drug that has been sold online as a The synthesis of 4-MeO-PCP was first reported in 1965 by the medicinal chemist Victor Maddox.A 1999 review published by a chemist using the pseudonym John Q. Beagle suggested the potency of 4-MeO-PCP in man was reduced relative to PCP, two years later Beagle published a detailed description of the synthesis and qualitative effects of 4-MeO-PCP,